منابع مشابه
Tissue microarrays in urology.
The TMA is a high-throughput technique to assess thousands of different cores of pathological tissue simultaneously using morphological and molecular analyses, e.g. immunohistochemistry and in situ hybridization, whilst maintaining an accurate and efficient method of identifying each specific section. Using this technique an economy in cutting and staining can also be used, with an unprecedente...
متن کاملtissue microarrays, a revolution in pathology research
a long-lasting problem in the analysis of tissue samples is the time-consuming and repetitive process of histologic preparation and pathologic review of tissue sections. these two critical factors, innate nonuniformity in preparation and subjectivity of analysis, therefore limit the scientific and statistical thoroughness of tissue based studies. employing tissue microarray (tma) technique prov...
متن کاملTissue microarrays: construction and use.
Tissue microarrays (TMAs) enable high-throughput tissue analysis by selecting a large number of -paraffin-embedded donor tissue block cores and transferring these tissue cores into a positionally encoded array in the recipient TMA block. Once TMAs are constructed, a variety of analysis may be performed on the arrays including histochemical, immunohistochemical, or immunofluorescent staining, an...
متن کاملTissue microarrays: applications in genomic research.
The widespread application of tissue microarrays in cancer research and the clinical pathology laboratory demonstrates a versatile and portable technology. The rapid integration of tissue microarrays into biomarker discovery and validation processes reflects the forward thinking of researchers who have pioneered the high-density tissue microarray. The precise arrangement of hundreds of archival...
متن کاملEDITORIALS Tissue Microarrays for Hypothesis Generation
Decades of hypothesis-driven research have led to the discovery of oncogenes and tumor suppressors that affect carcinogenesis. With the advent of powerful genomic and proteomic microarray techniques, a different scientific paradigm is emerging—one in which hypotheses are generated based on the evaluation of global gene expression in cells or tissues. Tissue microarrays are also useful to interr...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2004
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3700172